Top 10 Leading Causes Of Death, 2021

 

Rank (1) Cause of death Number of deaths Rate (2)
1 Heart disease 695,547 173.8
2 Malignant neoplasms (cancer) 605,213 146.6
3 COVID-19 416,893 104.1
4 Accidents (unintentional injuries) 224,935 64.7
5 Cerebrovascular diseases (stroke) 162,890 41.1
6 Chronic lower respiratory diseases 142,342 34.7
7 Alzheimer's disease 119,399 31.0
8 Diabetes 103,294 25.4
9 Chronic liver disease and cirrhosis 56,585 14.5
10 Kidney disease 54,358 13.6
  All other causes 882,775 25.5
  All deaths 3,464,231 879.7
(1) Based on number of deaths. (2) Deaths per 100,000 U.S. standard population. Source: National Center for Health Statistics, National Vital Statistics System, Mortality.