Top 15 Major Causes of Death, 2015
      Age-adjusted death rate (1)
Rank Cause of death Number of deaths Rate Percent change from 2014
1 Heart disease 633,842 168.5 0.9%
2 Malignant neoplasms (tumors) 595,930 158.5 -1.7
3 Chronic lower respiratory diseases 155,041 41.6 2.7
4 Accidents (unintentional injuries) 146,571 43.2 6.7
5 Cerebrovascular diseases (stroke) 140,323 37.6 3.0
6 Alzheimer's disease 110,561 29.4 15.7
7 Diabetes 79,535 21.3 1.9
8 Influenza and pneumonia 57,062 15.2 0.7
9 Kidney disease 49,959 13.4 1.5
10 Intentional self-harm (suicide) 44,193 13.3 2.3
11 Septicemia 40,773 11.0 2.8
12 Chronic liver disease and cirrhosis 40,326 10.8 3.8
13 Hypertension (3) 32,200 8.5 3.7
14 Parkinson's disease 27,972 7.7 4.1
15 Pneumonitis due to solids and liquids 19,803 5.3 3.9
  All other causes 538,539 NA NA
  All deaths 2,712,630 733.1 1.2%
(1) Per 100,000 population; factors out differences based on age. (2) Less than 0.1 percent. (3) Essential (primary) hypertension and hypertensive renal disease. NA=Not applicable. Source: National Center for Health Statistics.