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Top 10 States By Drug Poisoning Deaths And Death Rates, 2021 (1)
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  By number of deaths   By deaths per 100,000 people
Rank State Number of 
of deaths		 Deaths per
100,000 people (2)		 Rank State Number of 
of deaths		 Deaths per
100,000 people
1 California 10,901 26.6 1 West Virginia 1,501 90.9
2 Florida 7,827 37.5 2 District of Columbia 3,813 56.6
3 New York 5,842 28.7 3 Kentucky 2,463 55.9
4 Pennsylvania 5,449 43.2 4 Delaware 2,381 55.6
5 Ohio 5,397 48.1 5 Ohio 513 54.0
6 Texas 4,984 16.8 6 Tennessee 1,052 51.6
7 North Carolina 3,981 39.2 7 Maryland 5,397 48.1
8 Tennessee 3,813 56.6 8 Louisana 611 47.1
9 Illinois 3,762 29.0 9 Pennsylvania 5,449 43.2
10 Michigan 3,089 31.5 10 Maine 2,811 43.0

(1) Drug overdose caused by prescription and illegal drugs.

Source: Centers for Disease Control and Prevention, National Center for Health Services.

 

Archived Tables

Top 10 States By Drug Poisoning Deaths And Death Rates, 2019 (1)
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  By number of deaths   By deaths per 100,000 people
Rank State Number of
deaths		 Deaths per
100,000 people		 Rank State Number of
deaths		 Deaths per
100,000 people
1 California 6,198 15.0 1 West Virginia 870 52.8
2 Florida 5,268 25.5 2 Delaware 435 48.0
3 Pennsylvania 4,377 35.6 3 District of Columbia 311 43.2
4 Ohio 4,251 38.3 4 Ohio 4,251 38.3
5 New York 3,617 18.2 5 Maryland 2,369 38.2
6 Texas 3,136 10.8 6 Pennsylvania 4,377 35.6
7 New Jersey 2,805 31.7 7 Connecticut 1,214 34.7
8 Illinois 2,790 21.9 8 Kentucky 1,380 32.5
9 Michigan 2,385 24.4 9 Massachusetts 2,210 32.1
10 Maryland 2,369 38.2 10 New Hampshire 407 32.0

(1) Drug overdose caused by prescription and illegal drugs.

Source: National Center for Health Statistics.

 
Top 10 States By Drug Poisoning Deaths And Death Rates, 2020 (1)
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  By number of deaths   By deaths per 100,000 people (2)
Rank State Number of 
of deaths		 Deaths per
100,000 people (2)		 Rank State Number of 
of deaths		 Deaths per
100,000 people
1 California 8,908 21.8 1 West Virginia 1,330 81.4
2 Florida 7,231 35.0 2 District of Columbia 424 58.1
3 Ohio 5,204 47.2 3 Kentucky 2,083 49.2
4 Pennsylvania 5,168 42.4 4 Delaware 444 47.3
5 New York 4,965 25.4 5 Ohio 5,204 47.2
6 Texas 4,172 14.1 6 Tennessee 3,034 45.6
7 Illinois 3,549 28.1 7 Maryland 2,771 44.6
8 North Carolina 3,146 30.9 8 Louisana 1,896 42.7
9 Tennessee 3,034 45.6 9 Pennsylvania 5,168 42.4
10 New Jersey 2,840 32.1 10 Maine 496 39.7

(1) Drug overdose caused by prescription and illegal drugs.
(2) Rates are age-adjusted using the direct method and the 2000 U.S. standard population, except for age-specific crude rates. All rates are per 100,000 population.

Source: Centers for Disease Control and Prevention.