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Top 10 States By Drug Poisoning Deaths And Death Rates, 2022 (1)

  By number of deaths   By deaths per 100,000 people
Rank State Number of deaths Deaths per
100,000 people		 Rank State Number of deaths Deaths per
100,000 people
1 California 10,952 26.9 1 West Virginia 1,335 80.9
2 Florida 7,551 35.2 2 District of Columbia 451 64.3
3 New York 6,358 31.4 3 Tennessee 3,825 56.0
4 Texas 5,489 18.2 4 Delaware 549 55.3
5 Pennsylvania 5,169 40.9 5 Louisana 2,376 54.5
6 Ohio 5,144 45.6 6 Maine 707 54.3
7 North Carolina 4,310 41.8 7 Kentucky 2,271 53.2
8 Illinois 3,849 30.0 8 New Mexico 1,024 50.3
9 Tennessee 3,825 56.0 9 Vermont 276 45.9
10 Michigan 2,997 30.7 10 Ohio 5,144 45.6

(1) Drug overdose caused by prescription and illegal drugs.

Source: Centers for Disease Control and Prevention, National Center for Health Services.

Top 10 States By Drug Poisoning Deaths And Death Rates, 2021 (1)

  By number of deaths   By deaths per 100,000 people
Rank State Number of 
of deaths		 Deaths per
100,000 people (2)		 Rank State Number of 
of deaths		 Deaths per
100,000 people
1 California 10,901 26.6 1 West Virginia 1,501 90.9
2 Florida 7,827 37.5 2 District of Columbia 3,813 56.6
3 New York 5,842 28.7 3 Kentucky 2,463 55.9
4 Pennsylvania 5,449 43.2 4 Delaware 2,381 55.6
5 Ohio 5,397 48.1 5 Ohio 513 54.0
6 Texas 4,984 16.8 6 Tennessee 1,052 51.6
7 North Carolina 3,981 39.2 7 Maryland 5,397 48.1
8 Tennessee 3,813 56.6 8 Louisana 611 47.1
9 Illinois 3,762 29.0 9 Pennsylvania 5,449 43.2
10 Michigan 3,089 31.5 10 Maine 2,811 43.0

(1) Drug overdose caused by prescription and illegal drugs.

Source: Centers for Disease Control and Prevention, National Center for Health Services.

Top 10 States By Drug Poisoning Deaths And Death Rates, 2020 (1)

  By number of deaths   By deaths per 100,000 people (2)
Rank State Number of 
of deaths		 Deaths per
100,000 people (2)		 Rank State Number of 
of deaths		 Deaths per
100,000 people
1 California 8,908 21.8 1 West Virginia 1,330 81.4
2 Florida 7,231 35.0 2 District of Columbia 424 58.1
3 Ohio 5,204 47.2 3 Kentucky 2,083 49.2
4 Pennsylvania 5,168 42.4 4 Delaware 444 47.3
5 New York 4,965 25.4 5 Ohio 5,204 47.2
6 Texas 4,172 14.1 6 Tennessee 3,034 45.6
7 Illinois 3,549 28.1 7 Maryland 2,771 44.6
8 North Carolina 3,146 30.9 8 Louisana 1,896 42.7
9 Tennessee 3,034 45.6 9 Pennsylvania 5,168 42.4
10 New Jersey 2,840 32.1 10 Maine 496 39.7

(1) Drug overdose caused by prescription and illegal drugs.
(2) Rates are age-adjusted using the direct method and the 2000 U.S. standard population, except for age-specific crude rates. All rates are per 100,000 population.

Source: Centers for Disease Control and Prevention.